Official Site of the ANR Estimate
Exploring Molded Interconnect Device technologies for MRI probes
Research
In the last decades, the progress in the field of tissue engineering for regenerative medicine has been tremendous. However, there is still no effective method to evaluate non-invasively in vitro and in vivo engineered tissues. Therefore, the main objective of ESTIMATE is to democratize non-invasive imaging for the characterization of engineered tissues from the synthesis to the implantation stage. In this context, Magnetic Resonance Imaging is proposed as the modality of choice for this project in combination with Molded Interconnect Device technology. Thanks to its capability of integration in three dimensions, this one allows combining more functions, reducing the number of components, simplifying the assembly. The expected result is a turnkey preclinical MRI technology aiming to accurately monitor engineered tissues quality. The developed technology could lead to a breakthrough in regenerative medicine. Moreover ESTIMATE will facilitate the validation of new imaging biomarkers.term goal is to identify and characterize the scientific mechanisms specific to our principal areas of research. You can read on to find out more about these projects below.
People
Simon Lambert (PI)
Assistant Professor UCBL (CREATIS)
Simon Lambert (39 years old) received a double Master degree in physics instrumentation and in material science from ENSPG Grenoble and Politecnico di Torino in 2006. Then he developed dedicated MR coils during his PhD at university PARIS Saclay. During his post doc at Paris U773 (2011-2013) and King’s College London (2013-2015), his research topics were on new methods applied to clinical and preclinical MRI. More specifically he worked on electromagnetic simulations and characterization of monolithic very small superconducting coils for mouse brain imaging. After his PhD, he moved to a clinical environment and applied research on advanced methodological MRI developments for liver disease. At Kings College London he introduced a new MRE and MR-diffusion method able to link tissue microstructure with macroscopic measurements. He is currently assistant professor at Lyon 1. His current research interests include design of new RF coils, and development of innovative MRI methods to characterized tissue microarchitecture. ESTIMATE represents a combination of this previous fundamental works dedicated to RF coil design and to applied MRI techniques developed during the past decade.
First MRI sensor prototype
Manufacturing compact, miniature devices required for small samples imaging is still challenging. Here we investigate the feasibility of metalyzing 3D printing subtrates to develop a volume coil dedicated to both small in-vitro / ex-vivo samples and in vivo mouse brain imaging. In order to validate the use of metalized 3D printed process to build MRI coil we build one reference Helmholtz coil made with copper tape wrapped around the coil mount and one with the same geometry using this new technology. First demonstration on bench and in imaging that copper metallization technology can be performed to build volume coil.
Available Positions
Get Involved
Any time
Internship
If you are interested by the project ESTIMATE and more specifically in Instrumentation, sensors, electromagnetism, magnetic resonance imaging, elastography, you can apply for an internship. Please send CV at simon.lambert@univ-lyon1.fr
As soon as possible
Post-doctorate (2 years)
If you are interested by the project ESTIMATE and more specifically in Instrumentation, sensors, electromagnetism, magnetic resonance imaging, elastography, you can apply for a 2 years Post-doc. Please send CV and references at simon.lambert@univ-lyon1.fr
Contact Us
